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KMID : 0438219730100010363
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Korea University Medical Journal
1973 Volume.10 No. 1 p.363 ~ p.370
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Effects of Acute Renal Ischemia on Glycolysis in Rabbits Kidney Cortex and Medulla
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Abstract
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Effects of acute renal ischemia on glycolysis were studied in the rabbit kidney slices. Kidney slices were taken from papilla, inner medulla, outer medulla and cortical regions which were incubated in the medium of Krebs-Ringer solution at 38˚C for an hour after renal arterial or venous occlusion for an hour.
1. The glucose concentration in medium was progressively decreased from slices of papilla to cortex in the control group, whereas the progressive increase to cortex were observed in the occluded groups.
2. In case of renal vein occlusion, there was noted less the amount of glucose than artery occlusion and increase of glucose concentration in other three parts except papilla.
3. Lactic acid production was markedly increased by addition of glucose in medium in occluded groups.
4. In case of renal artery occlusion, the production of lactic acid was more accentuated than in renal vein.
5. In case of renal vein occlusion, effects of acute renal ischemia including lactic acid production were noted only at papilla.
Ischemia resulted in increases in glycolytic rates of at least 2 to 5 fold in different experimental regions of rabbit kidney. The coincident changes in glucose concentrations show which steps were facilitated to make this increase in flux take place, i.e. which steps control glycolysis in kidney. It would therefore appear that over-all glycolytic capacity in kidney slices was not reduced by renal arterial or venous occlusion.
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KEYWORD
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